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Abstract Many quiescent galaxies discovered in the early Universe by JWST raise fundamental questions on when and how these galaxies became and stayed quenched. Making use of the latest version of the semianalytic model GAEA that provides good agreement with the observed quenched fractions up toz∼ 3, we make predictions for the expected fractions of quiescent galaxies up toz∼ 7 and analyze the main quenching mechanism. We find that in a simulated box of 685 Mpc on a side, the first quenched massive (M_⋆∼ 10¹¹M_⊙), Milky Way–mass, and low-mass (M_⋆∼ 10^9.5M_⊙) galaxies appear atz∼ 4.5,z∼ 6.2, and beforez= 7, respectively. Most quenched galaxies identified at early redshifts remain quenched for more than 1 Gyr. Independently of galaxy stellar mass, the dominant quenching mechanism at high redshift is accretion disk feedback (quasar winds) from a central massive black hole, which is triggered by mergers in massive and Milky Way–mass galaxies and by disk instabilities in low-mass galaxies. Environmental stripping becomes increasingly more important at lower redshift.